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-synuclein, which happens to be a key ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) stress, propose that dysfunction from the intracellular proteinase devices, which include ubiquitin-proteasome program or lysosomal technique, which gets rid of
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